The 13 Best Herbs for Stress | The Botanical Institute (2023)

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Anghelescu, I. G., Edwards, D., Seifritz, E., & Kasper, S. (2018). Stress management and the role of Rhodiola rosea: a review. International journal of psychiatry in clinical practice, 22(4), 242–252. https://doi.org/10.1080/13651501.2017.1417442

Amsterdam, J. D., Li, Y., Soeller, I., Rockwell, K., Mao, J. J., & Shults, J. (2009). A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. Journal of clinical psychopharmacology, 29(4), 378–382. https://doi.org/10.1097/JCP.0b013e3181ac935c

Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., & Merali, Z. (2003). Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine : international journal of phytotherapy and phytopharmacology, 10(8), 640–649. https://doi.org/10.1078/0944-7113-00374

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Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255–262. https://doi.org/10.4103/0253-7176.106022

Cropley, M., Banks, A. P., & Boyle, J. (2015). The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytotherapy research : PTR, 29(12), 1934–1939. https://doi.org/10.1002/ptr.5486

Edwards, D., Heufelder, A., & Zimmermann, A. (2012). Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study. Phytotherapy research : PTR, 26(8), 1220–1225. https://doi.org/10.1002/ptr.3712

Haybar, H., Javid, A. Z., Haghighizadeh, M. H., Valizadeh, E., Mohaghegh, S. M., & Mohammadzadeh, A. (2018). The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Clinical nutrition ESPEN, 26, 47–52. https://doi.org/10.1016/j.clnesp.2018.04.015

Hanus, M., Lafon, J., & Mathieu, M. (2004). Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Current medical research and opinion, 20(1), 63–71. https://doi.org/10.1185/030079903125002603

Janda K, Wojtkowska K, Jakubczyk K, Antoniewicz J, Skonieczna-Żydecka K. Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. Nutrients. 2020 Dec 19;12(12):3894. doi: 10.3390/nu12123894. PMID: 33352740; PMCID: PMC7766837.

Jawna-Zboińska, K., Blecharz-Klin, K., Joniec-Maciejak, I., Wawer, A., Pyrzanowska, J., Piechal, A., Mirowska-Guzel, D., & Widy-Tyszkiewicz, E. (2016). Passiflora incarnata L. Improves Spatial Memory, Reduces Stress, and Affects Neurotransmission in Rats. Phytotherapy research : PTR, 30(5), 781–789. https://doi.org/10.1002/ptr.5578

Jothie Richard, E., Illuri, R., Bethapudi, B., Anandhakumar, S., Bhaskar, A., Chinampudur Velusami, C., Mundkinajeddu, D., & Agarwal, A. (2016). Anti-stress Activity of Ocimum sanctum: Possible Effects on Hypothalamic-Pituitary-Adrenal Axis. Phytotherapy research : PTR, 30(5), 805–814. https://doi.org/10.1002/ptr.5584

Kalman DS, Feldman S, Feldman R, Schwartz HI, Krieger DR, Garrison R. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J. 2008 Apr 21;7:11. doi: 10.1186/1475-2891-7-11. PMID: 18426577; PMCID: PMC2359758.

Kuribara, H., Stavinoha, W. B., & Maruyama, Y. (1999). Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice. The Journal of pharmacy and pharmacology, 51(1), 97–103.

Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine, 98(37), e17186. https://doi.org/10.1097/MD.0000000000017186

Mao, J. J., Xie, S. X., Keefe, J. R., Soeller, I., Li, Q. S., & Amsterdam, J. D. (2016). Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23(14), 1735–1742. https://doi.org/10.1016/j.phymed.2016.10.012

McCaffrey, R., Thomas, D. J., & Kinzelman, A. O. (2009). The effects of lavender and rosemary essential oils on test-taking anxiety among graduate nursing students. Holistic nursing practice, 23(2), 88–93. https://doi.org/10.1097/HNP.0b013e3181a110aa

Nematolahi, P., Mehrabani, M., Karami-Mohajeri, S., & Dabaghzadeh, F. (2018). Effects of Rosmarinus officinalis L. on memory performance, anxiety, depression, and sleep quality in university students: A randomized clinical trial. Complementary therapies in clinical practice, 30, 24–28. https://doi.org/10.1016/j.ctcp.2017.11.004

Olsson, E. M., von Schéele, B., & Panossian, A. G. (2009). A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta medica, 75(2), 105–112. https://doi.org/10.1055/s-0028-1088346

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Ranjbar M, Firoozabadi A, Salehi A, Ghorbanifar Z, Zarshenas MM, Sadeghniiat-Haghighi K, Rezaeizadeh H. Effects of Herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial. Integr Med Res. 2018 Dec;7(4):328-332. doi: 10.1016/j.imr.2018.08.001. Epub 2018 Aug 10. PMID: 30591886; PMCID: PMC6303415.

Reis, L. S., Pardo, P. E., Oba, E., Kronka, S., & Frazatti-Gallina, N. M. (2006). Matricaria chamomilla CH12 decreases handling stress in Nelore calves. Journal of veterinary science, 7(2), 189–192. https://doi.org/10.4142/jvs.2006.7.2.189

Reay, J., Wetherell, M. A., Morton, E., Lillis, J., & Badmaev, V. (2020). Sceletium tortuosum (Zembrin® ) ameliorates experimentally induced anxiety in healthy volunteers. Human psychopharmacology, 35(6), 1–7. https://doi.org/10.1002/hup.2753

Rolland, A., Fleurentin, J., Lanhers, M. C., Misslin, R., & Mortier, F. (2001). Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae). Phytotherapy research : PTR, 15(5), 377–381. https://doi.org/10.1002/ptr.884

Salve J, Pate S, Debnath K, Langade D. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus. 2019 Dec 25;11(12):e6466. doi: 10.7759/cureus.6466. PMID: 32021735; PMCID: PMC6979308.

Sarris, J., Stough, C., Bousman, C. A., Wahid, Z. T., Murray, G., Teschke, R., Savage, K. M., Dowell, A., Ng, C., & Schweitzer, I. (2013). Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. Journal of clinical psychopharmacology, 33(5), 643–648. https://doi.org/10.1097/JCP.0b013e318291be67

Saxena RC, Singh R, Kumar P, Negi MP, Saxena VS, Geetharani P, Allan JJ, Venkateshwarlu K. Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2012;2012:894509. doi: 10.1155/2012/894509. Epub 2011 Oct 3. PMID: 21977056; PMCID: PMC3185238.

Swart, A. C., & Smith, C. (2016). Modulation of glucocorticoid, mineralocorticoid and androgen production in H295 cells by Trimesemine™, a mesembrine-rich Sceletium extract. Journal of ethnopharmacology, 177, 35–45. https://doi.org/10.1016/j.jep.2015.11.033

Talbott, S. M., Talbott, J. A., & Pugh, M. (2013). Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition, 10(1), 37. https://doi.org/10.1186/1550-2783-10-37

Viola, H., Wasowski, C., Levi de Stein, M., Wolfman, C., Silveira, R., Dajas, F., Medina, J. H., & Paladini, A. C. (1995). Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta medica, 61(3), 213–216. https://doi.org/10.1055/s-2006-958058

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Wolfson, P., & Hoffmann, D. L. (2003). An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Alternative therapies in health and medicine, 9(2), 74–78.

Yamada, K., Miura, T., Mimaki, Y., & Sashida, Y. (1996). Effect of inhalation of chamomile oil vapour on plasma ACTH level in ovariectomized-rat under restriction stress. Biological & pharmaceutical bulletin, 19(9), 1244–1246. https://doi.org/10.1248/bpb.19.1244

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