Ramelteon: MedlinePlus Drug Information (2022)

pronounced as (ram el' tee on)

  • Why is this medication prescribed?
  • How should this medicine be used?
  • Other uses for this medicine
  • What special precautions should I follow?
  • What special dietary instructions should I follow?
  • What should I do if I forget a dose?
  • What side effects can this medication cause?
  • What should I know about storage and disposal of this medication?
  • In case of emergency/overdose
  • What other information should I know?
  • Brand names

Ramelteon is used to help patients who have sleep-onset insomnia (difficulty falling asleep) fall asleep more quickly. Ramelteon is in a class of medications called melatonin receptor agonists. It works similarly to melatonin, a natural substance in the brain that is needed for sleep.

Ramelteon comes as a tablet to take by mouth. It is usually taken once a day, no earlier than 30 minutes before bedtime. Do not take ramelteon with or shortly after a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ramelteon exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

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Swallow the tablets whole; do not split, chew, or crush them.

You may become sleepy soon after you take ramelteon. After you take ramelteon, you should complete any necessary bedtime preparations and go to bed. Do not plan any other activities for this time. Do not take ramelteon if you will be unable to remain asleep for 7 to 8 hours after taking the medication.

Your insomnia should improve within 7 to 10 days after you begin treatment with ramelteon. Call your doctor if your insomnia does not improve during this time or gets worse at any time during your treatment.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ramelteon and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking ramelteon,

  • tell your doctor and pharmacist if you are allergic to ramelteon, any other medications, or any of the ingredients in ramelteon tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor if you are taking fluvoxamine (Luvox). Your doctor will probably tell you not to take ramelteon while you are taking this medication.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); cimetidine (Tagamet); clarithromycin (Biaxin, in Prevpac); fluoroquinolones including ciprofloxacin (Cipro, Proquin XR), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), others; HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for anxiety, pain or seizures; nefazodone; rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); sedatives; other sleeping pills; ticlopidine (Ticlid); and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with ramelteon, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor if you have ever thought about killing yourself or planned or tried to do so, and if you have or have ever had chronic obstructive pulmonary disease (COPD, damage to the lungs that makes breathing difficult) or other lung disease, sleep apnea (condition in which you briefly stop breathing many times during the night) or other breathing problems, depression, mental illness, or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking ramelteon, call your doctor.
  • you should know that ramelteon may make you drowsy during the daytime. Do not drive a car or operate machinery until you know how this medication affects you.
  • do not drink alcohol during your treatment with ramelteon. Alcohol can make the side effects of ramelteon worse.
  • you should know that some people who took ramelteon got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, or were involved in other activities while partially asleep. After they woke up, these people were usually unable to remember what they had done. Call your doctor right away if you find out that you have been driving or doing anything else unusual while you were sleeping.
  • you should know that your mental health may change in unexpected ways while you are taking this medication. It is hard to tell if these changes are caused by ramelteon or if they are caused by physical or mental illnesses that you already have or suddenly develop. Tell your doctor right away if you experience any of the following symptoms: agitation, anxiety, frenzied or abnormally excited mood, hallucinations (seeing things or hearing voices that do not exist), nightmares, memory problems, new or worsening depression, thinking about or trying to kill yourself, and any other changes in your usual thoughts, mood, or behavior. Be sure that your family knows which symptoms may be serious so that they can call the doctor if you are unable to seek treatment on your own.
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Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.

Ramelteon should only be taken at bedtime. If you did not take ramelteon at bedtime and you are unable to fall asleep, you may take ramelteon if you will be able to remain in bed for 7 to 8 hours afterward. Do not take ramelteon if you are not ready to go to sleep and stay asleep for at least 7 to 8 hours.

Ramelteon may cause side effects. Tell your doctor if either of these symptoms are severe or do not go away:

  • drowsiness or tiredness
  • dizziness

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • swelling of the tongue or throat
  • difficulty swallowing or breathing
  • feeling that the throat is closing
  • nausea
  • vomiting
  • irregular or missed menstrual periods
  • milky discharge from the nipples
  • decreased sexual desire
  • fertility problems

Ramelteon may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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  • Rozerem®
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How safe is ramelteon? ›

Bottom Line. Ramelteon is safe and effective for decreasing the time to persistent sleep in patients with chronic insomnia. It does not have the potential for abuse or dependence that sedative hypnotics have and is not a controlled substance.

Does ramelteon work better than melatonin? ›

Ramelteon significantly reduced wakefulness over a wide dosage range with effects lasting up to 6 hours, in contrast to the effects of exogenous melatonin lasting up to 2 hours. Furthermore, ramelteon was found to be about 10 times more potent than melatonin in promoting sleep.

What is the pill ramelteon used for? ›

Ramelteon belongs to the group of medicines called central nervous system (CNS) depressants (medicines that slow down the nervous system). Ramelteon is used to treat insomnia (trouble in sleeping). Ramelteon helps you get to sleep faster and sleep through the night.

How long can you take ramelteon for? ›

Ramelteon helps you get to sleep faster and sleep through the night. In general, when sleep medicines are used every night for a long time, they may lose their effectiveness. In most cases, sleep medicines should be used only for short periods of time, such as 1 or 2 days, and generally for no longer than 1 or 2 weeks.

Does ramelteon affect blood pressure? ›

Chronic (but not acute) administration of Ramelteon (in drinking water, 8 mg/kg/day, from 4 to 12 weeks of age) attenuated age-associated increase of systolic blood pressure (tail-cuff method) by 45%, and age-associated body weight gain by 30%.

Is ramelteon safe in elderly? ›

In older adults, ramelteon is rapidly absorbed after oral administration, reaches peak serum concentrations within 1 to 2 hours, and is not associated with adverse pharmacodynamic effects (eg, psychomotor or memory impairment) even at twice the therapeutic dose.

How does ramelteon make you feel? ›

By binding to your body's MT1 and MT2 receptors, ramelteon mimics the effects of melatonin, meaning you'll gradually feel tired and ready to go to bed after using it. Studies of ramelteon show that it works effectively as a sleeping pill.

What is best sleeping pill for elderly? ›

In the elderly, nonbenzodiazepines such as zolpidem, eszopiclone, zaleplon, and ramelteon are safer and better tolerated than tricyclic antidepressants, antihistamines, and benzodiazepines. Pharmacotherapy should be recommended only after sleep hygiene is addressed, however.

How strong is ramelteon? ›

Dosage Forms And Strengths

ROZEREM is available in an 8 mg strength tablet for oral administration.

What is ramelteon side effects? ›

Common side effects of Rozerem include:
  • dizziness,
  • tiredness,
  • daytime drowsiness,
  • nausea, or.
  • worsening sleep problems.

How long does it take for ramelteon to take effect? ›

Your insomnia should improve within 7 to 10 days after you begin treatment with ramelteon. Call your doctor if your insomnia does not improve during this time or gets worse at any time during your treatment.

Is ramelteon similar to Ambien? ›

Ramelteon (Rozerem) is used to treat insomnia by making it easier to fall asleep. It is not habit-forming and has fewer side effects than other sleep medications like zolpidem (Ambien), but may be more expensive.

What medication is used for long term insomnia? ›

Benzodiazepines that have been approved by the FDA for treating chronic insomnia include estazolam, flurazepam (Dalmane), temazepam (Restoril), quazepam (Doral), and triazolam (Halcion). Rapidly acting drugs with shorter half-lives (i.e., estazolam, triazolam, and temazepam) are preferred.

Can I just stop taking ramelteon? ›

Unlike many drugs used for treating insomnia, Rozerem is not addictive, and it is not a controlled substance. Rozerem also does not cause withdrawal symptoms or rebound insomnia when it is stopped.

Should you take melatonin with ramelteon? ›

Using melatonin together with ramelteon may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.

What are the side effects of ramelteon? ›

Common side effects of Rozerem include:
  • dizziness,
  • tiredness,
  • daytime drowsiness,
  • nausea, or.
  • worsening sleep problems.

How strong is ramelteon? ›

Dosage Forms And Strengths

ROZEREM is available in an 8 mg strength tablet for oral administration.

How long does it take for Rozerem to work? ›

Ramelteon (Rozerem) should help with insomnia after 7 to 10 days. If your insomnia worsens or isn't getting better, it may be caused by another condition. It's important to talk to your provider to re-examine the cause of your insomnia so that they can help find the best treatment for you.

Does ramelteon cause vivid dreams? ›

Shortly after initiation of ramelteon, he described vivid nightmares leading to discontinuation of ramelteon. The nightmares ameliorated with ramelteon discontinuation. Ramelteon is well tolerated with a favorable side-effect profile.


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