Obesity: New guidelines rank best weight loss drugs (2023)

Obesity: New guidelines rank best weight loss drugs (1)Share on Pinterest
  • Researchers conducted a meta-analysis of different FDA-approved anti-obesity drugs.
  • They recommended four drugs alongside lifestyle changes to treat obesity when lifestyle interventions alone are insufficient.
  • Expert commentators note that access due to cost remains a hurdle for these drugs becoming mainstream.

The prevalence of obesity in the United States increased from 30.5% in 1999–2000 to 41.9% in 2019–2020. Obesity is related to many health complications, including cardiovascular disease, stroke, and certain kinds of cancer, including colon cancer.

While lifestyle interventions are key to managing obesity, they have limited efficacy and durability for many. Pharmaceutical interventions have thus been developed and approved for long-term management of the condition.

However, such drugs are limited in use. A small number of providers make up over 90% of prescriptions, partially due to a lack of familiarity with existing medications and limited insurance coverage.

Recently, the American Gastroenterological Association (AGA) analyzed current pharmaceutical therapies for obesity and created new guidelines on to treat the condition.

They noted that for adults with overweight and obesity who do not respond adequately to lifestyle interventions, long-term pharmacological therapy is recommended.

“Obesity is now affecting close to 50% of U.S. adults and is emerging as a major global pandemic with real health and economic impacts,” Dr. Yuval Cohen, cofounder and CEO of Corbus Pharmaceuticals, not involved in the study, told Medical News Today.

“The combination of education, awareness, social action, and medicinal therapy — where needed — should be a top global healthcare priority,” he added.

“The new guidelines were greatly needed as the previous ones were based on older and outdated data; new research has shown that lowering the criteria for surgery will have a huge, beneficial impact on a larger group of patients,” Dr. Mir Ali, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, not involved in the study, also told MNT.

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The new guidelines appear in Gastroenterology.

The researchers analyzed various studies investigating nine Food and Drug Administration (FDA)-approved anti-obesity medications to treat adults with a body mass index (BMI) of 27 kilograms per square meter (kg/m2) and above.

After analyzing the results, the researchers found that four drugs approved for long-term use have moderate or large weight loss effects with few negative side effects. The drugs were:

  • semaglutide, 2.4 milligrams (mg)
  • liraglutide, 3 mg
  • phentermine-topiramate extended-release (ER)
  • naltrexone-bupropion ER.

They noted that, when used alongside lifestyle interventions, each of the drugs was linked to a total body weight loss of between 3% and 10.8%.

Some studies also reported 15% total body weight loss, although the researchers noted this outcome was comparably rarer.

Dr. Chrisopher McGowen, board-certified gastroenterologist, internist, and obesity medicine specialist at True You Weightloss, not involved in the study, told MNT:

“[Semaglutide and liraglutide] are a tremendous advance for the treatment of obesity. Weight loss of 15% in 1 year is phenomenal and can have a true impact on patient health and medical comorbidities. We simply did not have these options in the past, aside from surgical modalities.”

The researchers noted, however, that FDA-approved anti-obesity medications should not be used by pregnant women, and that the drugs may increase the risk of hypoglycemia in those with type 2 diabetes.

They further wrote that doctors should exercise caution when treating those taking medications to lower blood pressure, as well as those with eating disorders.

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The researchers noted that orlistat should be avoided for those with obesity or overweight with weight-related complications due to generally small weight loss results — 2,78% total body weight loss — and negative side effects, including flatulence and fecal incontinence.

“Semaglutide is a class of drugs originally designed to treat type 2 diabetes,” explained Dr. Benjamin F. Voight, associate professor of systems pharmacology and translational therapeutics and genetics at the University of Pennsylvania, not involved in the study.

“Previous work has suggested that the mechanism could include reduced appetite and food cravings, better control of eating, and lower relative preference for fatty, energy-dense foods,” he added.

“Liraglutide is a GLP-1 agonist and functions as an appetite suppressant. This is thought to be mediated through both peripheral and central nervous system pathways, by modulating different types of neurons important for controlling recognition of appetite satiety,” he noted.

Dr. Aleem Kanji, board-certified internist and endocrinologist at Ethos Endocrinology, Houston, TX, not involved in the study, told MNT that “[p]hentermine-topiramate ER (Qsymia) has mechanisms from each medication of the combination drug. Phentermine increases the release of norepinephrine in the brain resulting in appetite suppression.”

“Topiramate is believed to also result in appetite suppression through enhancement of GABA (gamma-aminobutyric acid) and other mechanisms in the brain,” he explained.

“Weight loss mechanisms of naltrexone-bupropion ER (Contrave) are thought to be decreased appetite through activation of the POMC [proopiomelanocortin] neurons and decreased food cravings through the mesolimbic dopamine pathway, known as the reward pathway,” noted Dr. Kanji.

Why medication?

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When asked why some people with obesity may not respond to lifestyle changes alone, Dr. Lucas Carr, associate professor in the Department of Health and Human Physiology at the University of Iowa, not involved in the study, told MNT:

“Obesity is a complex disease with biological, genetic, environmental, and behavioral causes. Some individuals simply have a higher inherited risk of being obese due to their genetic makeup. Many individuals live an environment that contributes to their weight — e.g. toxic food environment, low access to resources.”

“There is a lot of variability in the quality of lifestyle weight loss interventions available. Some are based on sound scientific evidence, while others are not. In both cases, these are barriers that are mostly out of the individual’s control and not a case of low willpower, which is a common stereotype,” he added.

Dr. Jaime Almandoz, medical director at the Weight Wellness Program and Associate Professor of Internal Medicine at the University of Texas Southwestern Medical Center, not involved in the study, also told MNT that “[b]eyond this, when we lose weight, there are many biological changes that increase our risk for weight recurrence, called metabolic adaptation.”

“This can include changes in appetite, satiety, and energy expenditure, which promote the positive energy balance that drives weight gain,” he said.

Dr. McGowen explained how biological changes can increase the risk of weight recurrence. He said:

“Once a person is affected by overweight or obesity, the body has numerous intrinsic hormonal and neuroregulatory mechanisms designed to preserve that weight. When an individual diets and begins losing weight, there is an immediate compensatory increase in appetite and hunger driven by a rise in the hunger hormone, ghrelin. Similarly, the satiety hormone leptin decreases with weight loss, leading to less fullness when eating.”

“And finally, as one loses weight, their body becomes more efficient and uses less energy, meaning fewer calories expended. The combined result is that weight regain is near-inevitable following a diet and lifestyle program. This is exactly why pharmacotherapy and bariatric and metabolic surgery treatments are needed — to counteract these intrinsic weight-promoting mechanisms,” he added.

Limitations

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When asked about the guidelines’ limitations, Dr. Almandoz said: “The primary limitation to these guidelines is patient access to the anti-obesity medications that are recommended. Less than 2% of the eligible US population receives prescription anti-obesity medications, and when they do, the average duration of treatment is for less than 3 months.”

“This is due to many factors,” he noted, “which include healthcare providers and patients believing that anti-obesity medications are either ineffective or dangerous.”

“Insurance coverage of anti-obesity medications is a major barrier to treating obesity as the majority of people with commercial health insurance do not have anti-obesity medications on formulary. Although Medicare covers bariatric surgery, it does not cover any anti-obesity medications. Many of the newer anti-obesity medications (e.g. liraglutide and semaglutide), cost over a thousand dollars per month and are inaccessible to people without prescription coverage for these medications,” he added.

Dr. Voight further noted that as pharmacological interventions are relatively new, more study is needed to ascertain their safety and efficacy in pediatric patients.

Considering how these guidelines could influence treatment options for obesity, Dr. Kanji noted: “Treatment plans should take into account an individual’s medical conditions, presence of weight-related complications, dietary and cultural preferences, physical limitations, potential medication side effects, benefits and risks of each medication, and cost of medication.”

“These guidelines add to the current evidence the effectiveness of anti-obesity medications as part of a comprehensive treatment plan. It is my hope that the guidelines further demonstrate the need for anti-obesity medications to be more cost-effective and widely covered by health insurers,” he added.

Dr. Sameer Murali, obesity medicine specialist at University of Texas Health Houston and Memorial Hermann, not involved in the study, agreed that treatment plans should be personalized, he told MNT:

“[A] patient who struggles with night eating would likely be a poor responder to phentermine monotherapy given phentermine is a stimulant, suppresses appetite during the day, and may have little or no effect on appetite at night. A patient who is consuming a majority of their calories from sugar-sweetened beverages and/ or alcohol may be a poor responder to medication regimens largely aimed at reducing caloric intake from food.”

“Appropriate evaluation of mood disorders and disordered eating behavior may reveal additional pharmacologic targets that could enhance therapy,” he noted.

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“Given the scope of the obesity problem around the world, we certainly need more medical specialties offering evidenced-based treatments or, at a minimum, providing referrals to reputable programs and treatments,” Dr. David Sarwer, associate dean for research and director of the Center for Obesity Research and Education at the College of Public Health at Temple University in Philadelphia, not involved in the study, also commented.

FAQs

What is the new drug to treat obesity? ›

But semaglutide is the first of a new generation of highly effective hormone-based obesity medications. Semaglutide mimics a hormone called glucagon-like peptide-1 (GLP-1), which is secreted in the gut and targets receptors throughout the body, including the brain.

What is the best medication to treat obesity? ›

The most commonly used medications approved by the U.S. Food and Drug Administration (FDA) for the treatment of obesity include:
  • Bupropion-naltrexone (Contrave)
  • Liraglutide (Saxenda)
  • Orlistat (Alli, Xenical)
  • Phentermine-topiramate (Qsymia)
2 Sept 2021

What is the number 1 weight loss medication? ›

1. Lomaira, Adipex (phentermine) Phentermine is the most commonly prescribed weight-loss medication used in this country. It helps suppress appetite and make you feel fuller for longer.

What is the strongest weight loss prescription pill 2022? ›

Best Weight Loss Pills
  • PhenQ - Best weight loss pill overall.
  • Leanbean - Best weight loss pill for women.
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  • TrimTone - Best diet pill for belly fat.
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22 Jun 2022

How effective is Wegovy for weight loss? ›

Wegovy is injected once a week under the skin, with the dosage increasing every four weeks until it reaches 2.4 milligrams per week. Participants in a study had Wegovy injections for 68 weeks and lost an average of 15% to 18% of their body weight. The average for weight loss drugs already on the market is 7% to 9%.

What is the most successful weight loss pill? ›

Phentermine-Topiramate extended release (Qsymia) is the most effective weight loss drug available to date. It combines an adrenergic agonist with a neurostabilizer. Daily doses with four strengths start at 3.75/23mg to 15mg/92mg. Adults with migraines and obesity are good candidates for this weight loss medication.

What is the new weight loss shot? ›

About Mounjaro™ (tirzepatide) injection1

As the first and only FDA-approved GIP and GLP-1 receptor agonist, Mounjaro is a single molecule that activates the body's receptors for GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1).

What are four treatments for obesity? ›

Treatment for Overweight & Obesity
  • Healthy eating plan and regular physical activity.
  • Changing your habits.
  • Weight-management programs.
  • Weight-loss medicines.
  • Weight-loss devices.
  • Bariatric surgery.
  • Special diets.

Is Wegovy better than Phentermine? ›

For individuals who struggle with cravings and maintaining a strict diet, Phentermine may be the best option. However, individuals with a BMI of over 30 with risk factors such as diabetes may find Wegovy the better option.

How fast is weight loss on Wellbutrin? ›

How long does it take for Wellbutrin to work for weight loss? In people who lose weight as a side effect of Wellbutrin, it is possible to notice weight changes within eight weeks.

How do obese people start losing weight? ›

Change your diet.

“You have to become a good record-keeper,” Dr. Eckel said. “Reduce calories by 500 calories per day to lose about a one pound a week, or cut 1,000 calories a day to lose about two pounds a week.” Consider adding physical activity after reaching a minimum of 10 percent weight-loss goal.

What is the weekly shot for weight loss? ›

Wegovy (semaglutide) and Saxenda (liraglutide) are both injectable medications FDA-approved for weight loss. Wegovy is injected once weekly.

What is the name of the weight loss shot? ›

Saxenda® (liraglutide) injection 3 mg is an injectable prescription medicine used for adults with excess weight (BMI ≥27) who also have weight-related medical problems or obesity (BMI ≥30), and children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity to help them lose weight and keep the weight ...

What is the safest weight loss injection? ›

What is the best weight loss injection? Based on the evidence above, when comparing one to another, Saxenda comes out on top for us. It's the safest, most effective and produces the best results in our experience.

How can I get Saxenda for free? ›

Saxenda is available for free on the NHS for people with a BMI of over 35, and it is sometimes considered in those with a BMI over 30 with a weight-related condition such as high blood pressure, diabetes, or sleep apnoea.

Does Wegovy start working right away? ›

Wegovy starts working right after you inject a dose. But it may take several weeks or months before you notice weight loss or a decrease in appetite. How long does Wegovy stay in the body? Wegovy stays in the body for about 5 to 7 weeks after the last dose.

Why does Phentermine work so well? ›

It works by activating your sympathetic (“fight or flight”) nervous system, so it's called a “sympathomimetic” drug or “stimulant.” Phentermine may help lower your appetite, so people who take phentermine tend to eat less.

How long can I stay on Wegovy? ›

How long can you take Wegovy? Wegovy is one of six medications currently approved by the FDA for the long-term treatment of obesity. As such, it can be used for as long as it remains beneficial for weight loss and/or weight maintenance and is not causing intolerable side effects.

How quickly do you lose weight on Wegovy? ›

Weight loss may begin within the first 4 weeks of treatment with Wegovy, but the full effects of treatment may not be seen for several months or longer. In studies, weight loss was assessed over a 68-week period.

Is Wegovy or Ozempic better for weight loss? ›

Clinical trials of Wegovy® 2.4 mg showed average weight loss of 15.8% after 68 weeks. With Ozempic®, clinical trials showed an average 6% reduction in weight after one year (adults with an average starting weight of 197 pounds on 1.0 mg semaglutide per week).

Which supplement is best for weight loss for female? ›

2022's Best Weight Loss Supplements for Women
  • Leanbean– Best Fat Burner for Women (Editor Pick)
  • PhenQ– Best Natural Thermogenic.
  • Trimtone– Best Metabolism Booster For Women.
  • Zotrim– Best Appetite Suppressant for Women.
  • Powher Cut Burner – Best Stubborn Fat Burner.
18 Aug 2022

Which fat burner is best for weight loss for female? ›

TrimTone is a great fat burner for women. Its appetite suppressant effect will help you lose weight and stay on track. Leanbean is an excellent natural female fat burner. It uses plant extracts and minerals clinically proven to boost metabolism.

What vitamin can help with weight loss? ›

Vitamins B, D, iron, and magnesium are four well-known weight reduction vitamins. Vitamin B helps the body to convert food into energy. It also plays a role in metabolism and cell function. A lack of vitamin B can lead to fatigue and weight gain.

What is the new diet pill just approved by the FDA? ›

The freedom to focus on you, not your weight. Plenity® is indicated to aid weight management in adults with excess weight or obesity, a Body Mass Index (BMI) of 25–40 kg/m², when used in conjunction with diet and exercise.

Which is better for weight loss Saxenda or Ozempic? ›

However, the most important difference between the two is, that Saxenda is licenced for use as a weight loss medication in the UK and Ozempic is not. Unfortunately, there are a few unscrupulous websites and weight loss clinics, that are selling Ozempic, putting profit before safety.

How much weight will I lose taking Saxenda? ›

People taking Saxenda lost about 3% to 4% more weight than people taking a placebo. In another study, adults without Type 2 diabetes lost an average of 8% of their initial body weight. This was about 5% more weight loss than the placebo group.

How do you get rid of obesity fast? ›

29 Easy Ways to Lose Weight Naturally (Backed by Science)
  1. Add Protein to Your Diet. ...
  2. Eat Whole, Single-Ingredient Foods. ...
  3. Avoid Processed Foods. ...
  4. Stock Up on Healthy Foods and Snacks. ...
  5. Limit Your Intake of Added Sugar. ...
  6. Drink Water. ...
  7. Drink (Unsweetened) Coffee. ...
  8. Supplement With Glucomannan.
19 Jan 2022

What can a doctor do for weight loss? ›

How your GP can help you lose weight
  • assess your general health.
  • help identify the cause of your weight gain.
  • work out if there are any health issues causing you to put on weight.
  • discuss a plan to help you lose weight that suits you.

How do doctors treat obesity? ›

Weight loss drugs, approved by the U.S. Food and Drug Administration (FDA) for treating obesity, include: Beta-methyl-phenylethylamine (Fastin) This is a stimulant that increases fat metabolism. Orlistat (Xenical) This drug works by blocking about 30 percent of dietary fat from being absorbed.

How did Melissa McCarthy lose weight? ›

So How Did Melissa McCarthy Lose Weight? Melissa lost 70 lbs on a medically supervised all-liquid diet plan around 2003. “I'd never do that again. I felt starved and crazy half the time,” she explained to People Magazine.

How do I get my doctor to prescribe Wegovy? ›

It's in a drug class called glucagon-like peptide 1 (GLP-1) agonists and is used along with a reduced-calorie diet and increased exercise. To get a prescription for Wegovy, you must either have obesity or overweight and have a weight-related medical condition.

What happens when you stop taking Wegovy? ›

Indeed, weight gain after discontinuing the drugs is a concern; studies have found that two-thirds of patients gained the weight back after they stopped taking Wegovy. But obesity experts disagree about how long a patient should stay on the drugs.

Why was bupropion taken off the market? ›

"The [depressed] bulimic who hides that disease is thereby in the same risk category that they took the drug off the market for," Wolfe said. The study that prompted the drug's withdrawal from the market in 1986 showed that four out of 50 bulimic patients had seizures.

What is the downside of Wellbutrin? ›

Adverse reactions commonly encountered in subjects treated with WELLBUTRIN are agitation, dry mouth, insomnia, headache/migraine, nausea/vomiting, constipation, tremor, dizziness, excessive sweating, blurred vision, tachycardia, confusion, rash, hostility, cardiac arrhythmia, and auditory disturbance.

Who should not take Wellbutrin? ›

You should not take Wellbutrin if you are allergic to bupropion, or if you have: a seizure disorder; an eating disorder such as anorexia or bulimia; or. if you have suddenly stopped using alcohol, seizure medications, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).

How can I lose 100 pounds safely? ›

Here are 10 tips to help you lose 100 pounds safely.
  1. Track your calorie intake. To lose weight, your body needs to burn more calories than it consumes. ...
  2. Increase your fiber intake. ...
  3. Increase your protein intake. ...
  4. Cut back on refined carbs. ...
  5. Hold yourself accountable. ...
  6. Fill up on vegetables. ...
  7. Do more cardio. ...
  8. Try resistance training.
13 Jan 2020

Does Saxenda work immediately? ›

Both the Orlistat and Xenical treatments begin to work the first time you take a tablet with a meal. It will prevent some of the fat from being absorbed by the body. Saxenda begins working immediately, and you should start seeing results within 2 weeks.

How much weight can a morbidly obese person lose in a month? ›

Most very overweight or obese people can lose two to four pounds of fat per week without losing muscle mass. You'll be able to lose weight the fastest at the beginning of a diet, and your rate of weight loss will (and should) decrease as you approach your goal weight.

How much weight will I lose on Ozempic? ›

In a one year clinical trial done by the makers of Ozempic: People who weighed 197 pounds on average who took a 1mg dose of Ozempic lost 12 pounds on average. People who weighed 198 pounds on average who took a . 5mg dose of Ozempic lost 9 pounds on average.

Why am I not losing any weight on Saxenda? ›

One of the reasons why it's so hard to lose weight is because changes in your appetite hormone levels make it difficult to lose weight and keep it off.

Which is better Contrave or Saxenda? ›

Contrave has an average rating of 6.6 out of 10 from a total of 1938 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 25% reported a negative effect. Saxenda has an average rating of 7.5 out of 10 from a total of 1374 ratings on Drugs.com.

Which drug is FDA approved for weight loss? ›

The table below lists prescription drugs approved by the FDA for weight loss. The FDA has approved five of these drugs—orlistat (Xenical, Alli), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), liraglutide (Saxenda), and semaglutide (Wegovy)—for long-term use.

How long can you stay on Saxenda? ›

How Long Can I Use Saxenda® For? There is no set time limit for treatment with Saxenda however you should only continue using it for longer than 12 weeks if you demonstrate a weight loss of 5% when used in conjunction with a calorie-controlled diet and regular exercise.

Who qualifies for Wegovy? ›

Wegovy® is an injectable prescription medication for adults with obesity (BMI ≥30) or overweight (excess weight) (BMI ≥27) who also have weight-related medical problems used with a reduced-calorie meal plan and increased physical activity.

Do b12 injections help with weight loss? ›

There's no solid proof that vitamin B-12 shots, also called injections, help you lose weight. Vitamin B-12 is a water-soluble B complex vitamin. It's found naturally in many foods, such as meat, fish and dairy products. Vitamin B-12 is added to some foods and is available as a dietary supplement.

What foods should I avoid while taking Saxenda? ›

Foods to avoid while on Saxenda® to reduce side effects
  • Avoid fried, greasy, or fatty foods and foods high in sugar: These tend to be the toughest for your body to digest and the most likely to cause nausea while taking a GLP-1 medication.
  • Eat slowly, and eat smaller meals.
  • Eat foods that are light and bland.

Is there an injection to get rid of belly fat? ›

Celluform injections offer an effective long-term solution for these stubborn pockets of fat which are very common around the abdominal area. The treatment itself involves injecting the fat-dissolving product into various points across the problem area, directly into the fatty tissue beneath the skin.

When is tirzepatide available? ›

The SURMOUNT Phase 3 global clinical development program for tirzepatide began in late 2019 and has enrolled more than 5,000 people with obesity or overweight across six clinical trials, four of which are global studies. Results from SURMOUNT-2, -3 and -4 are anticipated in 2023.

Is tirzepatide approved for weight loss? ›

But it's also showing promising results in studies for people with obesity and overweight who don't have diabetes. Along with diet and exercise, tirzepatide can lead to significant weight loss — up to 20%. But it's not FDA-approved for weight loss yet.

What is the new weight loss shot? ›

About Mounjaro™ (tirzepatide) injection1

As the first and only FDA-approved GIP and GLP-1 receptor agonist, Mounjaro is a single molecule that activates the body's receptors for GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1).

How quickly does Wegovy work? ›

Wegovy starts working right after you inject a dose. But it may take several weeks or months before you notice weight loss or a decrease in appetite. How long does Wegovy stay in the body? Wegovy stays in the body for about 5 to 7 weeks after the last dose.

Is tirzepatide FDA-approved for obesity? ›

6 that the FDA granted tirzepatide a “fast track” review to be designated as a treatment for obesity. To receive this label, Lilly will be using data from the SURMOUNT-1 trial and the ongoing SURMOUNT-2 trial, which is investigating tirzepatide in people with type 2 diabetes who have excess weight or obesity.

Is tirzepatide better than semaglutide? ›

In the SURPASS-2 study, all doses of tirzepatide were superior to semaglutide 1 mg, a selective GLP-1 RA, in both HbA1c and body weight change from baseline at week 40 in patients with T2D taking metformin with HbA1c above target. The overall safety profile of tirzepatide was similar to that of semaglutide.

Is tirzepatide the same as Wegovy? ›

The two molecules do not act in precisely the same way: Wegovy is a GLP-1 analogue whereas tirzepatide is a GIP/GLP-1 agonist. Both are prone to gastrointestinal side-effects.

Is tirzepatide better than Ozempic? ›

The 1,900-patient pivotal Surpass-2 study found that all doses of tirzepatide tested were statistically significantly better than a 1mg dose of Ozempic in terms of HbA1c reduction and weight loss – without adding much, if anything, in terms of toxicity.

What is the name of the new FDA approved diet pill? ›

Semaglutide: The First New FDA-Approved Weight Loss Medication Since 2014. Key takeaways: Semaglutide (Wegovy) is the first once-weekly medication in its class that's FDA-approved to help with chronic weight management. It works best when used in combination with a healthy diet and exercise.

How long do you take Wegovy for weight loss? ›

How long can you take Wegovy? Wegovy is one of six medications currently approved by the FDA for the long-term treatment of obesity. As such, it can be used for as long as it remains beneficial for weight loss and/or weight maintenance and is not causing intolerable side effects.

Which is better for weight loss Saxenda or Ozempic? ›

However, the most important difference between the two is, that Saxenda is licenced for use as a weight loss medication in the UK and Ozempic is not. Unfortunately, there are a few unscrupulous websites and weight loss clinics, that are selling Ozempic, putting profit before safety.

What is the safest weight loss injection? ›

What is the best weight loss injection? Based on the evidence above, when comparing one to another, Saxenda comes out on top for us. It's the safest, most effective and produces the best results in our experience.

How can I get Saxenda for free? ›

Saxenda is available for free on the NHS for people with a BMI of over 35, and it is sometimes considered in those with a BMI over 30 with a weight-related condition such as high blood pressure, diabetes, or sleep apnoea.

Who should not take Wegovy? ›

If you or a family member have a history of medullary thyroid carcinoma (MTC), you shouldn't use Wegovy. MTC is a rare type of thyroid cancer. You also shouldn't use Wegovy if you have multiple endocrine neoplasia syndrome type 2 (MEN2). MEN2 is a rare genetic (inherited) condition that can cause thyroid cancer.

Do you gain weight after stopping Wegovy? ›

Indeed, weight gain after discontinuing the drugs is a concern; studies have found that two-thirds of patients gained the weight back after they stopped taking Wegovy.

Who qualifies for Wegovy? ›

Wegovy® is an injectable prescription medication for adults with obesity (BMI ≥30) or overweight (excess weight) (BMI ≥27) who also have weight-related medical problems used with a reduced-calorie meal plan and increased physical activity.

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